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Collectively, this study provides a solid foundation for future exploration into the impact of NNMTi-and diet-mediated changes to the gut microbiome in obese and lean populations, as well as future targets to investigate mechanistically with NNMTi treatment

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Therefore, comprehensive interventions targeting the "muscle-liver axis" (e.g., nutritional and exercise therapies) can provide multi-target strategies for MASLD/MASH by modulating these mechanisms [123]