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In view of the roles NAD + plays in various biochemical reactions such as redox reactions, ADP-ribosylation, protein deacetylation, and ADP-ribose cyclization [36,37,38], the impact of the decrease in NAD + on these biochemical reactions remain to be investigated

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Linsitinib, an IGF-1R inhibitor, attenuates disease development and progression in a model of thyroid eye disease