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In a prospective, case–control study in an Australian population, mean serum selenium decreased in parallel with increasing severity of Graves’ orbitopathy: 94·0 (sd 15·8) µg/l in GD, 86·9 (sd 15·0) µg/l in moderate-to-severe Graves’ orbitopathy and 86·1 (sd 13.4) µg/l in sight-threatening Graves’ orbitopathy ( P = 0·003) ( Reference Khong, Goldstein and Sanders 84 )