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Andrographolide has also been shown to partially inhibit the interaction of KEAP1 with CUL3 by targeting Cys151 in KEAP1 [309], while 15-deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ 2 ) is one exemplary drug preferentially targeting Cys288, and, in fact, the mutation of Cys151 does not affect Nrf2 induction by this compound [310]