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Research has shown that this stimulation occurs in a pulsatile and time-dependent manner, closely aligning with naturally observed secretion rhythms studied in endocrine models
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However, a 6-month RCT funded by Kyowa Hakko (n=54) found that taking 250 mg or 1,000 mg of Setria glutathione daily for 6 months significantly increased glutathione levels in blood, buccal cells, and erythrocytes, with the higher dose producing greater increases