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Moreover, TLR4 consists of two domains: an internal TIR (Toll-interleukin-1 receptor) and an external LRR (leucine-rich repeat)
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What this mechanism does NOT prove: Demonstrating that a peptide upregulates a growth factor in a petri dish or a rat does not establish that it produces the same signal at the same magnitude in a living human, that the signal persists long enough to matter, or that the clinical outcome (healed tendon, reduced pain) follows