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Alpha-1 Antitrypsin Deficiency and Oxidative Stress Among individuals with COPD, those with alpha-1 antitrypsin deficiency have a distinct pattern of oxidative stress characterized by an increase in exhaled breath nitric oxide, accelerated polymerization of oxidized Z-AT (Glu342Lys) protein which increases inflammation, and decreased serum glutathione and catalase before the appearance of COPD
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