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Within the thyroid, three iodothyronine deiodinases (DIO1, DIO2, and DIO3) depend on selenium for their enzymatic activity (127)
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In one mouse study, researchers found that the peptide reduced the pain felt by the animals in their paws when “placed on a mildly hot plate.” The authors explained that this could be because GHK is similar in structure to cimetidine, a histamine H2 receptor antagonist sometimes given to reduce pain in certain digestive conditions