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Approximately 5% of the inhaled O 2 is converted to reactive oxygen molecules with an unpaired number of electrons such as hydroxyl (OH·), superoxide anion (O 2 -·), hydrogen peroxide (H 2 O 2 ), oxygen singlet (O 2 ), hypochlorite (OCI-), nitric oxide (NO), and peroxynitrite (ONOO-) radicals
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In addition, higher levels of ROS have been shown to activate death receptors via downregulation of the FLIP—a protein that regulates apoptosis and functions as a key link between cell death and survival pathways (Wang et al
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