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Sources: [3] PubChem · reference structure · [1] PNAS · 1977 02 Where it came from In 1977, a Basel group including Guido Schoenenberger and Marcel Monnier reported a peptide from the blood of rabbits in which sleep had been induced, and linked it to delta-wave activity in recipient animals
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Importantly, clinical outcomes have been mixed: the large LOVIT randomized trial in adults with sepsis (“Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit,” Lamontagne and colleagues, New England Journal of Medicine, 2022, n=863) found that high-dose IV vitamin C was associated with a higher risk of death or persistent organ dysfunction than placebo