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In diet‑induced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF‑α and IL‑6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver

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Science 323 , 793–797 (2009)