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The testes require a precise balance of reactive oxygen species and antioxidants, and excessive homocysteine disrupts this balance, leading to oxidative stress [65], and subsequently impairs synthesis of testosterone
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Pediatric pharmacokinetics and long-term safety require clarification, particularly for polyphenols and carotenoids with intrinsically low oral bioavailability and potential interactions with conventional medications like antipsychotics or stimulants (Mousavinejad et al., 2018)