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The overall conformational flexibility of the ectodomain is also reduced by the constraints imposed by the disulfide-linked αCT elements that cross-link the two scLCDV1-VILP-bound L1-CR modules, resulting in the ectodomain’s points of membrane entry and the associated intracellular domains becoming further separated, rather than closer together as they do when IGF-1 binds

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Joint Pain/Stiffness: Some users report joint pain or stiffness (arthralgia), particularly when using higher doses