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The pattern has shifted from occasional flares to chronic low-grade acne with stress-triggered spikes, which suggests a systemic inflammatory state that topical care cannot address alone

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2.3.1 Ferroptosis and necroptosis The process of necroptosis is governed by the activation of receptor-interacting protein kinases (RIPK) 1/3, along with mixed lineage kinase domain-like protein (MLKL) (Müller et al