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10.1016/j.cmet.2010.09.004 276 TeraiM.LondinE.RochaniA.LinkE.LamB.KaushalG.et al

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Clinical studies remain limited, with the largest human trial involving 300 obese adults showing modest 2-3 kg weight loss over 12 weeks compared to placebo (Heffernan et al., International Journal of Obesity, 2001)