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Noteworthy, pharmacological induction of HO-1 has been reported to elicit neuroprotective effects against the neurotoxic Aβ-protein aggregates (Wang et al., 2016) and hamper the replication of HSV in a human neuronal cell line, although this was determined using HSV-2 (Ibáñez et al., 2017)

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Metal-Free Class Ie Ribonucleotide Reductase from Pathogens Initiates Catalysis with a Tyrosine-derived Dihydroxyphenylalanine Radical