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The likelihood of being symptom-free at the end of the trial was highest in the Pycnogenol group

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Thus, the separate (L-NAME or L-arginine) and combined (L-NAME+L-arginine) application of NO-agents [8], the implementation of all NO-function possibilities, and identification of the right one, for the each of the investigated negative-like symptoms items (L-NAME responsive or not, L-arginine responsive or not, mutual antagonization or not) might result with the demonstration of the multimodal NO-axis impact