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This association has been consistently replicated in studies of uveal melanoma, breast, and ovarian cancers, where CHAC1 upregulation marks advanced disease states ( CHAC1 upregulation in renal cell carcinoma (RCC) is linked to advanced tumor stage and higher histological grade, suggesting its role in cancer progression and malignancy (Wang et al., 2021)
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Do not apply to wounded or irritated skin or near the eyes and mouth