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Additionally, in patients diagnosed with the CCC, the HLA types HLA-C*07:04 or HLA-DQB1*03:03 were shown to be significantly linked to ME/CFS status when using the CCC (89)
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Because composite antioxidant assays reflect extracellular antioxidant pools and are influenced by multiple circulating factors beyond glutathione, future studies should incorporate functional endpoints alongside PK and expanded sulfur-metabolism panels to clarify physiological relevance and optimal dosing